Arachidonic acid and its metabolites (prostaglandins and leukotrienes) are now considered intracellular messengers.31 Arachidonic acid is a component of membrane phospholipids released either in a one-step process, after phospholipase A 2 (PLA 2) action, or a two-step process, after phospholipase C and DAG lipase actions. Metabolized by lipoxygenases, cyclooxygenases and cytochrome P450 monooxygenases. PLoS One 2011;6(12):e29662. The idea that AA may be harmful is derived from the following observations. No. Their biosynthesis, like that of the other bioactive lipids seen previously, is preceded by the release of AA from membrane phospholipids in a reaction catalyzed by phospholipase A2. Other articles where Arachidonic acid is discussed: carboxylic acid: Unsaturated aliphatic acids: Arachidonic acid is important because the human body uses it as a starting material in the synthesis of two kinds of essential substances, the prostaglandins and the leukotrienes, both of which are also unsaturated carboxylic acids. PubChem: 444899 Arachidonic acid is a polyunsaturated fatty acid (PUFA) with 20 carbon atoms and four double bonds in the cis (Z) configuration.Since the first double bond, with respect to the methyl end, is between carbon 6 and 7, it is an omega-6 or n-6 polyunsaturated fatty acid, and in shorthand notation is referred to as 20:4n-6.AA also belongs to the group of very long chain fatty acids or VLCFAs, that is, fatty acids with 20 carbon atoms or more. AA can also be converted into n6-docosapentaenoic acid (22: 5n6), through four reactions, of which the first three occur in the endoplasmic reticulum, whereas the last one in peroxisomes (see fig. A study published in 1975, in which 6 g/day of AA were administered to healthy volunteers, was stopped because of a marked increase in. HOW DOES IT WORK? Arachidonic acid comes under omega-6 fatty … It seems that the limiting factor is not the saturation of tissue arachidonic acid content, but the reaction catalyzed by Δ6-desaturase, since, for example, the levels of AA in blood phospholipids increase as a result of administration of γ-linolenic acid and AA itself. It is an essential dietary component in the muscle hypertrophy process. 126.96.36.199). Important cellular signaling mediator and precursor of eicosanoids. Mammalian cells and tissues are rich in AA, mostly present in their membrane phospholipids, in which it is arguably the most important unsaturated fatty acid, usually localized in the sn-2 position. In chemical structure, arachidonic acid is a carboxylic acid with a 20-carbon chain and four cis-double bonds; the first double bond is located at the sixth carbon from the omega end.. It has a role as a human metabolite, an EC 188.8.131.52 (carboxylesterase) inhibitor, a Daphnia galeata metabolite and a mouse metabolite. Metabolized by lipoxygenases, cyclooxygenases and cytochrome P450 monooxygenases. In the first step, AA is elongated to form adrenic acid (22: 4n6), in the reaction catalyzed by elongase 2 or Elovl2 (EC 184.108.40.206) or elongase 5 or Elovl5. Adrenic acid is elongated to n6-tetracosatetraenoic acid (24: 4n6), in the reaction catalyzed by elongase 2. n6-Tetracosatetraenoic acid is desaturated to form n6-tetracosapentaenoic acid (24: 5n6), in the reaction catalyzed by Δ6-desaturase (EC 220.127.116.11). The highest values are found in platelets, where it constitutes about 25% of the phospholipid fatty acids. Synonyms AA Reduction of arachidic acid yields arachidyl alcohol. Arachidic acid is used for the production of detergents, photographic materials and lubricants. Finally, DGLA is desaturated to form AA, in a reaction catalyzed by acyl-CoA (8-3)-desaturase, also referred as FADS1, acyl-CoA 5-desaturase or Δ5 desaturase (E.C.